This serious condition occurs when toxins from alcohol build up in your blood so fast your kidneys can’t maintain the proper fluid balance. Though it’s reversible with treatment, it can increase the risk of developing chronic kidney disease. Chronic alcohol consumption induces profound injury in several organs that may affect and aggravate the deleterious effect of ethanol on the kidney. Ethanol itself markedly induces the expression of the microsomal ethanol oxidation system (CYP2E1), producing reactive oxygen species as a byproduct.
This is because both alcohol and Glyxambi can lower your blood sugar, leading to an increased risk of severe low blood sugar. In addition, frequent alcohol use while taking Glyxambi can increase the risk of side effects, such as ketoacidosis (high ketones in the blood). Data from 10,030 participants were extracted from a de-identified dataset for analysis, and 9724 participants who had baseline data on alcohol consumption were included in our cohort. After excluding participants without data on serum Cr at baseline and the sixth phase of follow-up, data from 5729 participants were available for analysis.
General Health
As noted above, there is much to learn about alcoholic kidney disease and the complex interplay among multiple organs affected by alcohol consumption. Although research suggests several potential mechanisms by which alcohol may directly or indirectly affect the kidneys, they have not yet been validated experimentally. Future research will hopefully explore these hypotheses to provide a better understanding of alcoholic kidney injury. This article highlights the effects of other organs on kidney and renal function; however, it should be noted that alcoholic kidney injury itself may have negative metabolic consequences. One such complication is impaired vitamin D metabolism (Shankar et al. 2008), which may influence the function of several other organs, creating a vicious cycle.
But it can also happen if you have other health conditions, including a kidney infection. This 13-year cohort study revealed that participants with social or regular drinking habits had significantly reduced risk of the development of CKD when compared with non-drinkers. If you or a loved one has pre-existing kidney issues or are concerned about alcohol consumption and kidney health, it may be time to seek professional help. Our admissions navigators are available 24/7 at to discuss treatment options and give you the information you need to begin your road to recovery. Therefore, the effect of ethanol on renal antioxidant capacity varies with the concentration of ethanol and the duration of stimulation.
This can interfere with the functioning of the kidneys and other organs. The current study enrolled 45,200 subjects, which was a representative cohort for the Taiwan population. The follow-up period was 13 years, which was long enough to observe the development of CKD; thus, the research had appropriate power.
Drink in Moderation, If at All
In the kidneys, ROS is generated via both enzymatic and non-enzymatic processes 22,23,27,32,36,37. In addition, Das et al. reported that alcohol consumption impairs the ability of CAT to catalyze the decomposition of H2O2 in the kidneys 41. This subsequently promotes the conversion of H2O2 to the more reactive hydroxyl radicals, which cause damage in antioxidant capacities and mitochondria in renal cells 34,42,43. Samadi et al. also suggested that ethanol induces depression of nephrin and podocin in podocytes, which contributes to renal injury and proteinuria and is mediated by oxidative stress 44. Overall and subgroup analyses of the association between baseline alcohol consumption and decline in kidney function over 12 years in fully adjusted linear regression model.
What are the signs of kidney damage from alcohol?
Nowadays, many forms of ethyl alcohol are available, such as beer, wine, vodka, and other spirits, and these have become very popular among adults. The World Health Organization estimates that more than 55% of adults consume alcohol, and 140 million people worldwide have alcoholism 1,2. In fact, alcoholism is a serious problem in Asia, where 10.6–23.67% of men and 1.84–5.3% of women have a history of excessive alcohol consumption 3–9.
Notably, these mechanisms have not yet been validated experimentally in the kidney. Additional research is needed to clarify if alcohol does indeed promote kidney injury and the mechanisms by which alcohol-induced kidney injury may occur. In contrast, some studies find that heavy alcohol consumption may predict poorer outcome in patients with chronic kidney diseases (Kronborg et al. 2008; Shankar et al. 2006; White et al. 2009). For example, White and colleagues (2009) reported that heavier drinkers (those consuming more than 30 g celebrities famous fetal alcohol syndrome adults of alcohol/week) were at higher risk of incident albuminuria, which is typically a symptom of kidney disease. Japanese (Yamagata et al. 2007) and Italian (Buja et al. 2011) cohort studies revealed a U-shaped association between alcohol consumption and incidence of proteinuria. It is possible that the contradictory findings are the result of varying effects of different types of alcoholic beverages on the kidney, or the result of different alcohol consumption patterns in different countries.
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- In the univariable Cox model, it may not meet the proportional hazard assumption.
- Point and bars represent beta coefficients and 95% confidence intervals, respectively.
- Alcohol can not only directly damage the kidney, but also causes renal dysfunction by damaging other organs.
- Therefore, the relationship between heavy alcohol consumption and CKD may be affected by this sampling bias 16,79,117.
Oxidative stress occurs when the body cannot detoxify free radicals as fast as they are being produced, and it is pivotal in triggering alcohol-related tissue injury. Studies suggest that several mechanisms produce ROS in alcohol-damaged organs, including the liver (Cederbaum et al. 2009), heart (Tan et al. 2012; Varga et al. 2015), and kidney (Latchoumycandane et al. 2015). CYP2E1 is of particular interest when thinking about potential mechanisms for alcohol-related kidney damage. The body mainly metabolizes alcohol using the enzyme alcohol dehydrogenase, which is expressed primarily in the liver.